Deep Mutational Scanning Scientist - KU BRIC København

We are looking for a highly motivated and independent staff scientist to support our efforts in Deep Mutational Scanning and Multiplexed Assays of Variant Effects to commence 1 November 2026 or as soon as possible thereafter.

Our research

The research group investigates how cells maintain protein homeostasis through the protein quality control (PQC) system and how defects in these pathways contribute to disease and aging. Research activities combine molecular genetics, functional genomics, and advanced high-throughput technologies to dissect the mechanisms governing protein folding, degradation, and cellular stress responses.

A central focus is the development and application of Deep Mutational Scanning (DMS) approaches to systematically characterize the functional consequences of genetic variation at scale. By integrating DMS with genome-wide CRISPR screening and other multiplexed assays, the group aims to uncover sequence–function relationships, identify determinants of protein stability and degradation, and map the cellular pathways that influence variant effects. This work provides fundamental insights into PQC networks and contributes to improved interpretation of human genetic variation in health and disease.

Your job

You will join a multidisciplinary research team investigating cellular protein quality control using advanced high-throughput technologies. Your work will include cloning large cDNA libraries, conducting genome-wide CRISPR screens, and performing multiplexed assays to study the effects of genetic variants. The role requires close collaboration with researchers from diverse scientific backgrounds, integrating expertise from molecular biology, genetics, bioinformatics, and related fields.

Beyond your primary projects, you will support ongoing research activities across the group on an ad hoc basis, contributing technical expertise, troubleshooting, and experimental development where needed. You will also help disseminate knowledge within the lab by sharing best practices, training colleagues, and fostering a collaborative learning environment.

The position is embedded in an international and inclusive research setting that values teamwork, diversity, and interdisciplinary collaboration. You will contribute not only to scientific discovery but also to the smooth operation and supportive culture of the laboratory.

Profile

We are looking for a highly motivated and enthusiastic staff scientist with the following competencies and experience:

Essential experience and skills

• You have a PhD in Biochemistry or a related area.
• You have documented experience with large-scale DNA library cloning, screening and sequencing.
• Experienced with flow cytometry and FACS.
• You are experienced with DMS and NGS data analyses and visualization.
• You have an active interest in PQC degradation and DMS technologies.
• You have proven an ability to envision, plan and execute a research project.
• Good English skills, written and spoken.

Place of employment

The place of employment is at the Department of Biology, Ole Maaløes Vej 5, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and access to state-of-the-art facilities for sequencing and cell sorting.

Terms of employment

Employment will be as academic research staff. The average weekly working hours are 37 hours per week. The position is a fixed-term position limited to a period of 1.5 years (18 months). The starting date is 1 November 2026 or as soon as possible thereafter.

Employment will be in accordance with the provisions of the collective agreement between the Danish Ministry of Taxation and AC (the Danish Confederation of Professional Associations). The monthly salary will be based on the number of years of work experience (seniority) with the possibility to negotiate a salary supplement based on prior experience and qualifications. The employer will pay an additional 18.07 % to your pension fund.

Questions

For further information regarding the position, please contact Prof. Rasmus Hartmann-Petersen; rhpetersen@bio.ku.dk.

Application

Your application should be written in English and include:

• Letter of application addressing the requirements (max. one page).
• Curriculum Vitae
• List of publications
• A certified/signed copy of certificate(s) of education

Please submit your application by clicking on “Apply Now” below. Only online applications will be accepted.

Application deadline: 27 July 2026 at 23.59 CEST

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements. Interviews are expected to be held in week 35.

The University of Copenhagen wishes to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.

Denne stilling er publiceret af KU – SCIENCE BIO – BRIC via jobnet.dk